3-Prime solid supports have been perfected over many years, using a combination of internal development and collaboration with some of todays leading oligonucleotide scientists.
Prime Performance CPG is optimized for the trade-offs between parameters such as pore diameter, pore volume, and specific surface area, bulk density and ligand distribution, and is specifically intended for oligo synthesis applications. Our techniques of end-capping potentially active side-sites have also been perfected over many years to minimize n-x impurities.
We've also improved the performance of our premium LCAA linked nucleoside supports by using a proprietary linker co-developed by SIRNA Therapeutics. The rigid nature of this linker enables syntheses of higher yield and purity, regardless of sequence length. Our Aminopropyl-linked nucleoside supports provide a more cost-effective synthesis approach, with purities and yields that satisfy many common oligo applications.
Prime Performance PS is a polystyrene solid support that has been optimized for oligo synthesis. It has been developed to address applications where an organic polymeric support is preferred. Unlike many of the ultra-high loading polymer supports that swell extensively in synthesis solvents, Prime Performance PS expands by only 30%. This provides higher molar capacities in large scale, fixed volume applications.